interictal-like activity in vitro
نویسندگان
چکیده
1 INSERM U739, Faculté de Médecine Pitié-Salpêtrière, Paris, France 2 Institute for Psychology, Hungarian Academy of Sciences, Budapest, Hungary 3 National Institute of Neurosurgery, Budapest, Hungary 4 Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary 5 Epilepsy Unit, Hôpital Pitié-Salpêtrière, Paris, France 6 Neurosurgery Unit, Hôpital Pitié-Salpêtrière, Paris, France 7 Department of Information Technology, Péter Pázmány Catholic University, Budapest, Hungary
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Dose-dependent effects of morphine on hippocampal seizure
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The release of glutamate from astrocytes activates synchronous slow inward currents (SICs) in hippocampal pyramidal neurons, which are mediated by the NMDA receptor and represent a nonsynaptic mechanism to promote the synchronization of neuronal activity. Two recent studies demonstrate that SICs generate neuronal paroxysmal depolarizations resembling those typical of interictal epileptiform act...
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